Joha Park

Senior Computational Scientist at Intellia Therapeutics

E-mail:

[firstname][lastname] AT gmail.com

I’m a computational biologist specializing in sequencing and imaging data analysis. I majored in biology for my undergraduate at Seoul National University and joined the Narry Kim lab to study RNA biology. During my Ph.D., I carried out diverse next-generation sequencing (NGS) data analysis to study various coding and noncoding RNAs. Besides the standard NGS technologies such as bulk or single-cell RNA-seq, I have extensive experience in preparing and analyzing custom RNA-seq libraries. For example, I used fCLIP-seq to reveal the endogenously-expressed dsRNA binding repertoire of PKR, and TAIL-seq to profile global poly(A)-tail length to study mRNA poly(A) tail regulations.

After I joined the Chung lab as a postdoc, I focused on hydrogel-based tissue engineering (review) and microscopy imaging data analysis. I developed eMAP which maximally preserves epitopes by purely physical tissue-gel hybridization. It enables superresolution imaging on a cleared and expanded tissue-gel that maintains exceptional antigenicity. Typical datasets I analyzed were large-scale confocal/light-sheet microscopy images of those tissue-gel hybrids, which require dedicated machine learning techniques and efficient parallelization of computation.

As a scientist, my long-term research interest lies in single-cell and spatial genomics in the RNA biology and therapeutics contexts. I’m particularly interested in revealing cell-to-cell heterogeneity within the healthy and diseased tissue microenvironment. I believe cross-disciplinary approaches utilizing both high-throughput sequencing and imaging techniques would open an avenue for investigating tissue in greater detail at multiple scales, facilitating research and drug developement.


recent news

Apr 3, 2023 I have joined the Computational Sciences team at Intellia Therapeutics!
Feb 27, 2023 LARP1-poly(A) study is published online (finally!) (link)
May 24, 2022 LARP1-poly(A) study is accepted for publication in Nature Structural & Molecular Biology !
Apr 1, 2022 Appointed as a Picower Postdoctoral Fellow
Jan 13, 2022 eMAP is covered in a news article from Picower (link)

all news